Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC036
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-21 15:23
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl Madopar 250mg 4x1/2, caps Madopar HBS 125mg

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 13, 'TN': 11, 'TP': 29, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 2.956
timePerCircleCoV 0.190991
timePerCircleSlope -0.0414155
meanError 2.93995
tremorFreq 6.64062
tremorRelPower 16.6888
tremorGyroAmpMean 0.0536794
tremorGyroAmpSlope 0.0398629
tremorGyroAmpCoV 0.383588
tremorCoordAmpMean 0.0817391
tremorCoordAmpSlope -0.000149696
tremorCoordAmpCoV 0.173487
tremorAccAmpMean 0.046733
tremorAccAmpSlope 0.00948979
tremorAccAmpCoV 0.279717
tremorPcRelVar 0.528604
tremorPcX 0.142905
tremorPcY 0.989736

Circle Segment 1

Duration 4.28 s, Accuracy Estimate 2.51 (lower is better)

Circle Segment 2

Duration 3.2 s, Accuracy Estimate 2.169 (lower is better)

Circle Segment 3

Duration 3.4 s, Accuracy Estimate 2.097 (lower is better)

Circle Segment 4

Duration 2.64 s, Accuracy Estimate 3.115 (lower is better)

Circle Segment 5

Duration 2.8 s, Accuracy Estimate 2.374 (lower is better)

Circle Segment 6

Duration 2.6 s, Accuracy Estimate 2.887 (lower is better)

Circle Segment 7

Duration 2.4 s, Accuracy Estimate 3.194 (lower is better)

Circle Segment 8

Duration 2.6 s, Accuracy Estimate 3.102 (lower is better)

Circle Segment 9

Duration 2.56 s, Accuracy Estimate 3.234 (lower is better)

Circle Segment 10

Duration 3.08 s, Accuracy Estimate 4.718 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 7.084
timePerSpiralCoV 0.119765
timePerSpiralSlope -0.033229
meanError 2.93551
tremorFreq 5.85938
tremorRelPower 20.7572
tremorGyroAmpMean 0.098013
tremorGyroAmpSlope 0.00637672
tremorGyroAmpCoV 0.410277
tremorCoordAmpMean 0.134012
tremorCoordAmpSlope 0.00655547
tremorCoordAmpCoV 0.315847
tremorAccAmpMean 0.099868
tremorAccAmpSlope 0.00545338
tremorAccAmpCoV 0.276217
tremorPcRelVar 0.623862
tremorPcX -0.579006
tremorPcY 0.815324

Spiral Segment 1

Duration 8.0 s, Accuracy Estimate 2.945 (lower is better)

Spiral Segment 2

Duration 8.6 s, Accuracy Estimate 2.493 (lower is better)

Spiral Segment 3

Duration 7.36 s, Accuracy Estimate 3.074 (lower is better)

Spiral Segment 4

Duration 7.08 s, Accuracy Estimate 2.817 (lower is better)

Spiral Segment 5

Duration 7.04 s, Accuracy Estimate 2.654 (lower is better)

Spiral Segment 6

Duration 7.16 s, Accuracy Estimate 2.794 (lower is better)

Spiral Segment 7

Duration 6.88 s, Accuracy Estimate 2.616 (lower is better)

Spiral Segment 8

Duration 5.92 s, Accuracy Estimate 3.11 (lower is better)

Spiral Segment 9

Duration 7.08 s, Accuracy Estimate 3.172 (lower is better)

Spiral Segment 10

Duration 5.72 s, Accuracy Estimate 3.681 (lower is better)

Elel

eDurationMean 0.259483
eDurationStd 0.0280416
eDurationStdnorm 0.108067
eDurationMedian 0.255
eDurationQuartdelta 0.0375
eDurationQuartdeltanorm 0.147059
eDurationKurt 3.37098
eDurationTrenddiff 0
eDurationTrendratio 1
eWidthMean 3.30424
eWidthStd 0.845814
eWidthStdnorm 0.255978
eWidthMedian 3.159
eWidthQuartdelta 1.14075
eWidthQuartdeltanorm 0.361111
eWidthKurt 2.5871
eWidthTrenddiff 0.2925
eWidthTrendratio 1.09804
eHeightMean 6.72952
eHeightStd 1.49821
eHeightStdnorm 0.222632
eHeightMedian 6.435
eHeightQuartdelta 1.872
eHeightQuartdeltanorm 0.290909
eHeightKurt 3.29793
eHeightTrenddiff -0.351
eHeightTrendratio 0.946903
eAspectMean 0.502949
eAspectStd 0.131232
eAspectStdnorm 0.260925
eAspectMedian 0.478261
eAspectQuartdelta 0.187262
eAspectQuartdeltanorm 0.391548
eAspectKurt 2.77274
eAspectTrenddiff 0.0609079
eAspectTrendratio 1.12852
eSlantMean -0.12162
eSlantStd 0.136876
eSlantStdnorm -1.12543
eSlantMedian -0.141304
eSlantQuartdelta 0.19213
eSlantQuartdeltanorm -1.35969
eSlantKurt 4.04119
eSlantTrenddiff -0.0508168
eRtopMean 0.703253
eRtopStd 0.192981
eRtopStdnorm 0.274413
eRtopMedian 0.75
eRtopQuartdelta 0.256602
eRtopQuartdeltanorm 0.342136
eRtopKurt 3.11324
eRtopTrenddiff -0.0535714
eRbotMean 0.959591
eRbotStd 0.240598
eRbotStdnorm 0.25073
eRbotMedian 0.96
eRbotQuartdelta 0.317805
eRbotQuartdeltanorm 0.331046
eRbotKurt 2.46589
eRbotTrenddiff -0.0827228
eRrightMean 0.84311
eRrightStd 0.136362
eRrightStdnorm 0.161737
eRrightMedian 0.890244
eRrightQuartdelta 0.20856
eRrightQuartdeltanorm 0.234273
eRrightKurt 3.03168
eRrightTrenddiff -0.0587567
eRleftMean 0.460817
eRleftStd 0.110971
eRleftStdnorm 0.240813
eRleftMedian 0.431373
eRleftQuartdelta 0.118178
eRleftQuartdeltanorm 0.273959
eRleftKurt 3.59388
eRleftTrenddiff -0.0721745
lDurationMean 0.330556
lDurationStd 0.0492508
lDurationStdnorm 0.148994
lDurationMedian 0.33
lDurationQuartdelta 0.05375
lDurationQuartdeltanorm 0.162879
lDurationKurt 3.16921
lDurationTrenddiff 0.005
lDurationTrendratio 1.01538
lWidthMean 4.238
lWidthStd 1.69124
lWidthStdnorm 0.399066
lWidthMedian 3.627
lWidthQuartdelta 2.34
lWidthQuartdeltanorm 0.645161
lWidthKurt 2.79963
lWidthTrenddiff -1.42109e-14
lWidthTrendratio 1
lHeightMean 18.1827
lHeightStd 2.71035
lHeightStdnorm 0.149062
lHeightMedian 17.55
lHeightQuartdelta 4.24125
lHeightQuartdeltanorm 0.241667
lHeightKurt 2.49476
lHeightTrenddiff -2.925
lHeightTrendratio 0.852941
lAspectMean 0.236507
lAspectStd 0.0989659
lAspectStdnorm 0.418448
lAspectMedian 0.215789
lAspectQuartdelta 0.105006
lAspectQuartdeltanorm 0.486615
lAspectKurt 4.31542
lAspectTrenddiff 0.000993743
lAspectTrendratio 1.00461
lSlantMean -0.0945027
lSlantStd 0.0925496
lSlantStdnorm -0.979333
lSlantMedian -0.101449
lSlantQuartdelta 0.120493
lSlantQuartdeltanorm -1.18772
lSlantKurt 2.65162
lSlantTrenddiff -0.0973304
lRtopMean 0.694395
lRtopStd 0.180504
lRtopStdnorm 0.259944
lRtopMedian 0.714286
lRtopQuartdelta 0.222333
lRtopQuartdeltanorm 0.311266
lRtopKurt 3.3704
lRtopTrenddiff -0.0648148
lRbotMean 1.19432
lRbotStd 0.388952
lRbotStdnorm 0.325668
lRbotMedian 1.22
lRbotQuartdelta 0.480451
lRbotQuartdeltanorm 0.393812
lRbotKurt 3.18086
lRbotTrenddiff 0.0771429
lRrightMean 0.874623
lRrightStd 0.090587
lRrightStdnorm 0.103573
lRrightMedian 0.881119
lRrightQuartdelta 0.0995085
lRrightQuartdeltanorm 0.112934
lRrightKurt 4.4031
lRrightTrenddiff -0.0468947
lRleftMean 0.527962
lRleftStd 0.152543
lRleftStdnorm 0.288927
lRleftMedian 0.54717
lRleftQuartdelta 0.291899
lRleftQuartdeltanorm 0.53347
lRleftKurt 2.09873
lRleftTrenddiff 0.0394987

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

FITTS Short Modified

meanTouchScore 0.861558
sumTouchScores 16.3696
meanMovementTime 0.999167
numTouches 19
undershootPercentage 0
overshootPercentage 42.1053

FITTS Long Modified

meanTouchScore 0.769875
sumTouchScores 12.318
meanMovementTime 1.23633
numTouches 16
undershootPercentage 0
overshootPercentage 50

ZigZag

numZigzags 5
timePerZigzagMean 12.224
timePerZigzagCoV 0.326829
timePerZigzagSlope -0.173102
meanError 3.35925
tremorFreq 6.05469
tremorRelPower 21.3776
tremorGyroAmpMean 0.072312
tremorGyroAmpSlope 0.0109198
tremorGyroAmpCoV 0.428223
tremorCoordAmpMean 0.106662
tremorCoordAmpSlope 0.015657
tremorCoordAmpCoV 0.395185
tremorAccAmpMean 0.0764848
tremorAccAmpSlope 0.0119043
tremorAccAmpCoV 0.362731
tremorPcRelVar 0.733129
tremorPcX 0.315029
tremorPcY -0.949082

ZigZag Segment 1

Duration 18.68 s, Accuracy Estimate 2.486 (lower is better)

ZigZag Segment 2

Duration 10.72 s, Accuracy Estimate 3.714 (lower is better)

ZigZag Segment 3

Duration 13.16 s, Accuracy Estimate 2.825 (lower is better)

ZigZag Segment 4

Duration 10.2 s, Accuracy Estimate 3.672 (lower is better)

ZigZag Segment 5

Duration 8.36 s, Accuracy Estimate 4.1 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 9.64
timePerZigzagCoV 0.16688
timePerZigzagSlope -0.10166
zigzagHeightMean 76.0514
zigzagHeightCoV 0.0902927
zigzagHeightSlope 0.0420796
meanError 0.0435392
tremorFreq 6.34766
tremorRelPower 26.4986
tremorGyroAmpMean 0.0455302
tremorGyroAmpSlope -6.53578e-05
tremorGyroAmpCoV 0.280488
tremorCoordAmpMean 0.134702
tremorCoordAmpSlope 0.00396832
tremorCoordAmpCoV 0.256844
tremorAccAmpMean 0.0826112
tremorAccAmpSlope -0.00405211
tremorAccAmpCoV 0.173062
tremorPcRelVar 0.785599
tremorPcX -0.0933802
tremorPcY 0.995631

ZigZag Offset Segment 1

Duration 11.4 s, Accuracy Estimate 0.052 (lower is better)

ZigZag Offset Segment 2

Duration 10.44 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 3

Duration 10.08 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 4

Duration 9.12 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 5

Duration 7.16 s, Accuracy Estimate 0.063 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.5229273850972911}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.7534681177367137}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.2702391292510746}